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Our Goal

... is to utilize the neural circuits of the retina to reveal fundamental principles of neural computations at quantal resolution.

Research Overview

Our ability to see in vastly varying conditions depends critically on the outstanding performance of vision. Vision begins in the neural circuits of the retina, which operates with a remarkable fidelity. We study novel signal processing mechanisms and their adaptive dynamics at the synaptic and cellular-element level across the entire neural circuit of the retina.We do so by combining a battery of techniques allowing precise manipulations of local signal and noise statistics in a well-defined retinal circuit relying on genetically modified mice, molecularly tailored artificial visual pigment molecules, and cutting-edge electrophysiological recording techniques. We seek to understand the functional implications of novel retinal signal processing mechanisms by correlating our results with the output of the entire visual system measured in mouse behavioral experiments and human psychophysics experiments.

Open Positions

We have currently no available positions. However, we are always interested in hearing from talented people with high motivation in neuroscience. For postdoc candidates, previous experience in patch clamp electrophysiology and/or computational neuroscience is valued. For more information, please send an email to Petri Ala-Laurila including your CV, statement of research interests and the names of potential references:
petri.ala-laurila@helsinki.fi

Publications


Takeshita, D., Smeds, L. & Ala-Laurila, P. (2017). Processing of single-photon responses in the mammalian On and Off retinal pathways at the sensitivity limit of vision. Phil. Trans. R. Soc. B 372. [PDF]

Ala-Laurila, P. (2016). Visual Neuroscience: How Do Moths See to Fly at Night? Current Biology 26, R229–R246. [PDF]

Vartanian, G.V., Li, B.Y., Chervenak, A.P., Walch O.J., Pack W., Ala-Laurila, P. & Wong K.Y. (2015). Melatonin Suppression by Light in Humans Is More Sensitive Than Previously Reported. J Biol Rhythms 30, 351-354. [PDF]

Ala-Laurila, P. & Rieke, F (2014). Coincidence Detection of Single-Photon Responses in the Inner Retina at the Sensitivity Limit of Vision. Current Biology 24, 2888-2898.
[ PDF | COMMENTARY ]

Ala-Laurila, P., Greschner, M., Chichilnisky & Rieke, F (2011). Cone photoreceptor contributions to noise and correlations in the retinal output. Nature Neuroscience 14, 1309-1316. [PDF]

Ala-Laurila, P., Cornwall, M.C., Crouch, R.K., & Kono, M. (2009). The action of 11-cisretinol on cone opsins and intact cone photoreceptors. J Biol Chem 284, 16492-16500. [PDF]

Estevez, M.E., Kolesnikov, A.V., Ala-Laurila, P., Crouch, R.K., Govardovskii, V.I., & Cornwall, M.C. (2009). The 9-methyl group of retinal is essential for rapid Meta II decay and phototransduction quenching in red cones. J Gen Physiol 134, 137-150. [PDF]

Ala-Laurila, P., Donner, K., Crouch, R.K., & Cornwall, M.C. (2007). Chromophore Switch from 11-cis-dehydroretinal (A2) to 11-cis-retinal (A1) Decreases Dark Noise in Salamander Red Rods. J Physiol 585, 57-74. [PDF]

Cornwall M.C., & Ala-Laurila P. (2007). A perfect marriage: molecular genetics ties the knot with electrophysiology in studies of visual transduction. J Gen Physiol 130, 7-10. [PDF]

Jokela-Määttä, M., Smura, T., Aaltonen, A., Ala-Laurila, P., & Donner, K. (2006). Visual pigments of Baltic Sea fishes of marine and limnic origin. Vis Neurosci 24, 389-398. [PDF]

Kolesnikov, A.V., Ala-Laurila, P., Shukolyukov, S.A., Crouch, R.K., Wiggert, B., Estevez, M.E., Govardovskii, V.I., & Cornwall, M.C. (2006). Visual cycle and its metabolic support in gecko photoreceptors. Vision Res 47, 363-374. [PDF]

Estevez, M.E., Ala-Laurila, P., Crouch, R.K., & Cornwall, M.C. (2006). Turning Cones Off: The Role of the 9-Methyl Group of Retinal in Red Cones. J Gen Physiol 128, 671-685. [PDF]

Pahlberg, J., Lindström, M., Ala-Laurila, P., Fyhrquist-Vanni, N., Koskelainen, A., & Donner, K. (2005). The photoactivation energy of the visual pigment in two spectrally different populations of Mysis relicta (Crustacea, Mysida). J Comp Physiol A Neuroethol Sens Neural Behav Physiol 191, 837-844. [PDF]

Ala-Laurila, P., Donner, K., & Koskelainen, A. (2004). Thermal activation and photoactivation of visual pigments. Biophys J 86, 3653-3662. [PDF]

Ala-Laurila, P., Pahlberg, J., Koskelainen, A., & Donner, K. (2004). On the relation between the photoactivation energy and the absorbance spectrum of visual pigments. Vision Res 44, 2153-2158. [PDF]

Tsina, E., Chen, C., Koutalos, Y., Ala-Laurila, P., Tsacopoulos, M., Wiggert, B., Crouch, R.K., & Cornwall, M.C. (2004). Physiological and microfluorometric studies of reduction and clearance of retinal in bleached rod photoreceptors. J Gen Physiol 124, 429-443. [PDF]

Ala-Laurila, P., Albert, R.-J., Saarinen, P., Koskelainen, A., & Donner, K. (2003). The thermal contribution to photoactivation in A2 visual pigments studied by temperature effects on spectral properties. Vis Neurosci 20, 411-419. [PDF]

Ala-Laurila, P., Saarinen, P., Albert, R., Koskelainen, A., & Donner, K. (2002). Temperature effects on spectral properties of red and green rods in toad retina. Vis Neurosci 19, 781-792. [PDF]

Koskelainen, A., Ala-Laurila, P., Fyhrquist, N., & Donner, K. (2000): Measurement of thermal contribution to photoreceptor sensitivity. Nature 403, 220-223. [ PDF | COMMENTARY ]

Ala Laurila's team

Members

Petri Ala-Laurila, DSc (Tech)

Academy Research Fellow & Principal Investigator

I am a “kid” who loves science. I did my PhD in Finland (2000- 2003, Engineering Physics, Helsinki University of Technology) and thereafter moved to the USA, where I did two distinct postdoctoral periods: in Boston (2004-2008, laboratory of Dr. Carter Cornwall) and in Seattle (2008-2012, laboratory of Dr. Fred Rieke). The goal of my lab is to establish a new frontier in the Finnish neuroscience community focusing on signal processing in the mammalian retina.

Anna Stöckl, PhD

Postdoctoral Fellow

Throughout my scientific journey, I have been interested in how neural circuits process sensory information. During my PhD (2012-2016 at Lund University), I investigated visual neurons in the brain of hawkmoths to understand how they overcome the challenge of low signal and high noise levels their visual system faces at night. For my postdoc in Petri’s lab I will study how small populations of neurons in the mouse retina combat the noisy regimes their visual system faces in dim light, with particular focus on noise which is correlated between neurons of the population.

Daisuke Takeshita, PhD

Postdoctoral Fellow

I would like to understand how the brain works using a combination of experimental and computational techniques (note that the retina is an extension of the brain!).

Sanna Koskela, MSc

PhD student

I’ve always been fascinated by vision, in all its forms. After graduating in 2012 with a major in biology (University of Eastern Finland), I came to the University of Helsinki to learn more about neuroscience. Petri’s group provided the fascinating opportunity to study the visual system from single cells to behavior and to learn several valuable techniques.

Nataliia Martyniuk, MSc

PhD student

I believe that vision is the most important human sense, because it often gives the most immediate impression of the world. Visual perceptions arise in the neural circuits of the retina, which detect and encode the visual information and transmit it to the brain, which forms the basis for our decisions. I'm highly impressed with the technical capabilities and the level of innovation in the laboratory of Professor Petri Ala-Laurila and I am looking forward to be part of such a motivated and talented team.

For more information about my PhD program please visit the website:
http://www.uef.fi/web/biomep/doctoral-students

Lina Smeds, MSc

PhD student

I grew up in the small town of Porvoo, Finland. In 2009 I moved to Helsinki where I started to study biology with physiology and neuroscience as my major. I was happy to join the lab in June 2012 and started conducting behavioral experiments on mice. I enjoy challenges, and a need to learn and discover new things drives me to do research. My favorite motto that goes for my attitude towards both science and life in general is: "Don’t be pushed by your problems. Be led by your dreams."

Tuomas Turunen, MSc (Tech)

PhD student

In 2012, I recieved my Master's degree in computer science from Aalto University. The focus of my degree was on computer vision and object recognition. Out of pure interest after graduating, I developed firmware and signal processing for an embedded ultrasound sensor. In January 2013 Petri offered me a place designing the lighting conditions and camera setup for the behavioral experiments. In addition to a little tinkering, I also have the option to investigate the different methods of tracking mice. Who could have refused?

Sathish Narayanan

Master's Student

I am pursuing my Master's in bioinformatics at Aalto University. My research interests center in understanding the computational principles of the brain. I have a strong appetite for programming. Before my Master’s I was working as a software developer, technical evangelist in Infosys, India (2006 - 2010).

Jussi Tiihonen

Master's Student

I'm a Master's student at Aalto University with a major in Life Science Technologies. Research and scientific methods have interested me as long as I can remember. I'm glad to be able to do research while studying for the future.

Sami Minkkinen, MSc (Tech)

Laboratory Manager

I am a techie with a strong interest in science. I have a startup attitude and I like to design, create, and build both hardware and software. I have studied Engineering Physics, Biomedical Engineering, and Computer and Information Science at Aalto University. Besides this work, I have experience in programming, R&D, running a business, and patenting.

Former Members

Tony Azevedo, PhD

Postdoctoral Fellow

Tony is a California native, born and raised in the Bay Area who did his B.S. at Berkeley (Engineering Physics, 2005) and PhD. at University of Washington (Physiology and Biophysics, 2011). Tony joined our lab for the summer and autumn of 2012 for a short but productive postdoc period before starting his current postdoctoral training at Harvard. Tony’s project continues as a collaboration.

Matthew Dunkerley

Programmer

I am a person that is trying to get the most out of life. After graduating University in Australia with an IT degree majoring in mathematics, I worked for 2 years as a Systems Engineer at the largest Google Enterprise partner in the Asia Pacific. This enabled me to travel across Australia and Indonesia and develop great business relations. After this I was conscripted to the Finnish military and have now lived in Finland for 2 years.

Contact

Petri Ala-Laurila

Academy Research Fellow & PI
Department of Biosciences
P.O. Box 65 ( Viikinkaari 1 )
FIN-00014, University of Helsinki
Finland
Email: petri.ala-laurila@helsinki.fi

Assistant Professor
Department of Neuroscience and Biomedical Engineering
Aalto University School of Science
P.O. Box 12200 ( Rakentajanaukio 2C )
FI-00076 AALTO
Finland
Email: petri.ala-laurila@aalto.f